Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
Identifieur interne : 003918 ( Main/Exploration ); précédent : 003917; suivant : 003919Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
Auteurs : Nichola Johnson [Royaume-Uni] ; Frank Dudbridge [Royaume-Uni] ; Nick Orr [Royaume-Uni] ; Lorna Gibson [Royaume-Uni] ; Michael E. Jones [Royaume-Uni] ; Minouk J. Schoemaker [Royaume-Uni] ; Elizabeth J. Folkerd [Royaume-Uni] ; Ben P. Haynes [Royaume-Uni] ; John L. Hopper [Australie] ; Melissa C. Southey [Australie] ; Gillian S. Dite [Australie] ; Carmel Apicella [Australie] ; Marjanka K. Schmidt [Pays-Bas] ; Annegien Broeks [Pays-Bas] ; Laura J. Van Veer [Pays-Bas] ; Femke Atsma [Pays-Bas] ; Kenneth Muir [Royaume-Uni] ; Artitaya Lophatananon [Royaume-Uni] ; Peter A. Fasching [Allemagne, États-Unis] ; Matthias W. Beckmann [Allemagne] ; Arif B. Ekici [Allemagne] ; Stefan P. Renner [Allemagne] ; Elinor Sawyer [Royaume-Uni] ; Ian Tomlinson [Royaume-Uni] ; Michael Kerin [Irlande (pays)] ; Nicola Miller [Irlande (pays)] ; Barbara Burwinkel [Allemagne] ; Frederik Marme [Allemagne] ; Andreas Schneeweiss [Allemagne] ; Christof Sohn [Allemagne] ; Pascal Guénel [France] ; Therese Truong [France] ; Emilie Cordina [France] ; Florence Menegaux [France] ; Stig E. Bojesen [Danemark] ; B Rge G. Nordestgaard [Danemark] ; Henrik Flyger [Danemark] ; Roger Milne [Espagne] ; M Pilar Zamora [Espagne] ; Jose Ignacio Arias Perez [Espagne] ; Javier Benitez [Espagne] ; Leslie Bernstein [États-Unis] ; Hoda Anton-Culver [États-Unis] ; Argyrios Ziogas [États-Unis] ; Christina Clarke Dur [États-Unis] ; Hermann Brenner [Allemagne] ; Heiko Müller [Allemagne] ; Volker Arndt [Allemagne] ; Aida Karina Dieffenbach [Allemagne] ; Alfons Meindl [Allemagne] ; Joerg Heil [Allemagne] ; Claus R. Bartram [Allemagne] ; Rita K. Schmutzler [Allemagne] ; Hiltrud Brauch [Allemagne] ; Christina Justenhoven [Allemagne] ; Yon-Dschun Ko [Allemagne]Source :
- Breast Cancer Research : BCR [ 1465-5411 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antécédents gynécologiques et obstétricaux, Cytochrome P-450 CYP3A (génétique), Facteurs de l'âge, Facteurs de risque, Femelle, Génotype, Humains, Ménarche (génétique), Polymorphisme de nucléotide simple, Population d'origine européenne, Prédisposition génétique à une maladie, Préménopause (génétique), Sujet âgé, Tumeurs du sein (anatomopathologie), Tumeurs du sein (génétique), Âge de début, Études d'associations génétiques.
- MESH :
- anatomopathologie : Tumeurs du sein.
- génétique : Cytochrome P-450 CYP3A, Ménarche, Préménopause, Tumeurs du sein.
- Adulte, Adulte d'âge moyen, Antécédents gynécologiques et obstétricaux, Facteurs de l'âge, Facteurs de risque, Femelle, Génotype, Humains, Polymorphisme de nucléotide simple, Population d'origine européenne, Prédisposition génétique à une maladie, Sujet âgé, Âge de début, Études d'associations génétiques.
English descriptors
- KwdEn :
- Adult, Age Factors, Age of Onset, Aged, Breast Neoplasms (genetics), Breast Neoplasms (pathology), Cytochrome P-450 CYP3A (genetics), European Continental Ancestry Group, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Menarche (genetics), Middle Aged, Polymorphism, Single Nucleotide, Premenopause (genetics), Reproductive History, Risk Factors.
- MESH :
- chemical , genetics : Cytochrome P-450 CYP3A.
- genetics : Breast Neoplasms, Menarche, Premenopause.
- pathology : Breast Neoplasms.
- Adult, Age Factors, Age of Onset, Aged, European Continental Ancestry Group, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Middle Aged, Polymorphism, Single Nucleotide, Reproductive History, Risk Factors.
Abstract
We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the
We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.
We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01;
To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.
Url:
DOI: 10.1186/bcr3662
PubMed: 24887515
PubMed Central: 4522594
Affiliations:
- Allemagne, Australie, Danemark, Espagne, France, Irlande (pays), Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Bade-Wurtemberg, Bavière, Californie, Communauté de Madrid, District de Cologne, District de Haute-Bavière, District de Karlsruhe, District de Moyenne-Franconie, District de Stuttgart, District de Tübingen, Gueldre, Hollande-Septentrionale, Hovedstaden, Oxfordshire, Rhénanie-du-Nord-Westphalie, Victoria (État), Île-de-France
- Amsterdam, Bonn, Cologne, Copenhague, Erlangen, Heidelberg, Madrid, Melbourne, Munich, Nimègue, Oxford, Paris, Stuttgart, Tübingen
- Université d'Oxford, Université de Melbourne
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001627
- to stream Pmc, to step Curation: 001487
- to stream Pmc, to step Checkpoint: 001571
- to stream PubMed, to step Corpus: 003792
- to stream PubMed, to step Curation: 003678
- to stream PubMed, to step Checkpoint: 003678
- to stream Ncbi, to step Merge: 001A85
- to stream Ncbi, to step Curation: 001A85
- to stream Ncbi, to step Checkpoint: 001A85
- to stream Main, to step Merge: 003954
- to stream Main, to step Curation: 003918
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic variation at <italic>CYP3A</italic> is associated with age at menarche and breast cancer risk: a case-control study</title><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation wicri:level="1"><nlm:aff id="I1">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB</wicri:regionArea><wicri:noRegion>London SW3 6JB</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB</wicri:regionArea><wicri:noRegion>London SW3 6JB</wicri:noRegion></affiliation></author><author><name sortKey="Dudbridge, Frank" sort="Dudbridge, Frank" uniqKey="Dudbridge F" first="Frank" last="Dudbridge">Frank Dudbridge</name><affiliation wicri:level="1"><nlm:aff id="I3">Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT</wicri:regionArea><wicri:noRegion>London WC1E 7HT</wicri:noRegion></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation wicri:level="1"><nlm:aff id="I1">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB</wicri:regionArea><wicri:noRegion>London SW3 6JB</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB</wicri:regionArea><wicri:noRegion>London SW3 6JB</wicri:noRegion></affiliation></author><author><name sortKey="Gibson, Lorna" sort="Gibson, Lorna" uniqKey="Gibson L" first="Lorna" last="Gibson">Lorna Gibson</name><affiliation wicri:level="1"><nlm:aff id="I3">Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT</wicri:regionArea><wicri:noRegion>London WC1E 7HT</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Michael E" sort="Jones, Michael E" uniqKey="Jones M" first="Michael E" last="Jones">Michael E. Jones</name><affiliation wicri:level="1"><nlm:aff id="I4">Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J" last="Schoemaker">Minouk J. Schoemaker</name><affiliation wicri:level="1"><nlm:aff id="I4">Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Folkerd, Elizabeth J" sort="Folkerd, Elizabeth J" uniqKey="Folkerd E" first="Elizabeth J" last="Folkerd">Elizabeth J. Folkerd</name><affiliation wicri:level="1"><nlm:aff id="I5">The Academic Department of Biochemistry, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Academic Department of Biochemistry, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ</wicri:regionArea><wicri:noRegion>London SW3 6JJ</wicri:noRegion></affiliation></author><author><name sortKey="Haynes, Ben P" sort="Haynes, Ben P" uniqKey="Haynes B" first="Ben P" last="Haynes">Ben P. Haynes</name><affiliation wicri:level="1"><nlm:aff id="I5">The Academic Department of Biochemistry, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Academic Department of Biochemistry, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ</wicri:regionArea><wicri:noRegion>London SW3 6JJ</wicri:noRegion></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="I6">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation wicri:level="4"><nlm:aff id="I7">Genetic Epidemiology Department, Department of Pathology, The University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Department, Department of Pathology, The University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Dite, Gillian S" sort="Dite, Gillian S" uniqKey="Dite G" first="Gillian S" last="Dite">Gillian S. Dite</name><affiliation wicri:level="4"><nlm:aff id="I6">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation wicri:level="4"><nlm:aff id="I6">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name><affiliation wicri:level="1"><nlm:aff id="I8">Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation wicri:level="1"><nlm:aff id="I8">Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Van Veer, Laura J" sort="Van Veer, Laura J" uniqKey="Van Veer L" first="Laura J" last="Van Veer">Laura J. Van Veer</name><affiliation wicri:level="1"><nlm:aff id="I8">Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Atsma, Femke" sort="Atsma, Femke" uniqKey="Atsma F" first="Femke" last="Atsma">Femke Atsma</name><affiliation wicri:level="3"><nlm:aff id="I9">Sanquin, Radboud Universiteit Nijmegen, 6525 GA, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Sanquin, Radboud Universiteit Nijmegen, 6525 GA, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation wicri:level="1"><nlm:aff id="I10">Warwick Medical School, University of Warwick, Coventry CV4 7AJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Warwick Medical School, University of Warwick, Coventry CV4 7AJ</wicri:regionArea><wicri:noRegion>Coventry CV4 7AJ</wicri:noRegion></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation wicri:level="1"><nlm:aff id="I10">Warwick Medical School, University of Warwick, Coventry CV4 7AJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Warwick Medical School, University of Warwick, Coventry CV4 7AJ</wicri:regionArea><wicri:noRegion>Coventry CV4 7AJ</wicri:noRegion></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name><affiliation wicri:level="1"><nlm:aff id="I11">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Postfach 2306, D-91012 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Postfach 2306, D-91012 Erlangen</wicri:regionArea><wicri:noRegion>91012 Erlangen</wicri:noRegion><wicri:noRegion>91012 Erlangen</wicri:noRegion><wicri:noRegion>D-91012 Erlangen</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="I12">David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name><affiliation wicri:level="1"><nlm:aff id="I11">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Postfach 2306, D-91012 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Postfach 2306, D-91012 Erlangen</wicri:regionArea><wicri:noRegion>91012 Erlangen</wicri:noRegion><wicri:noRegion>91012 Erlangen</wicri:noRegion><wicri:noRegion>D-91012 Erlangen</wicri:noRegion></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B" last="Ekici">Arif B. Ekici</name><affiliation wicri:level="1"><nlm:aff id="I13">Institute of Human Genetics, Friedrich Alexander University Erlangen- Nuremberg, Schlossplatz 4, 91054 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Friedrich Alexander University Erlangen- Nuremberg, Schlossplatz 4, 91054 Erlangen</wicri:regionArea><wicri:noRegion>91054 Erlangen</wicri:noRegion><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Renner, Stefan P" sort="Renner, Stefan P" uniqKey="Renner S" first="Stefan P" last="Renner">Stefan P. Renner</name><affiliation wicri:level="1"><nlm:aff id="I11">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Postfach 2306, D-91012 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Postfach 2306, D-91012 Erlangen</wicri:regionArea><wicri:noRegion>91012 Erlangen</wicri:noRegion><wicri:noRegion>91012 Erlangen</wicri:noRegion><wicri:noRegion>D-91012 Erlangen</wicri:noRegion></affiliation></author><author><name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name><affiliation wicri:level="1"><nlm:aff id="I14">Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, Guy’s Hospital, Great Maze Pond, London SE1 9RT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, Guy’s Hospital, Great Maze Pond, London SE1 9RT</wicri:regionArea><wicri:noRegion>London SE1 9RT</wicri:noRegion></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation wicri:level="4"><nlm:aff id="I15">Welcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Welcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="I16">Oxford Biomedical Research Centre, University of Oxford, The Churchill Hospital, Old Road, Headington OX3 7LE Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Biomedical Research Centre, University of Oxford, The Churchill Hospital, Old Road, Headington OX3 7LE Oxford</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name><affiliation wicri:level="1"><nlm:aff id="I17">Surgery, Clinical Science Institute, Galway University Hospital and National University of Ireland, University Road, Galway, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Surgery, Clinical Science Institute, Galway University Hospital and National University of Ireland, University Road, Galway</wicri:regionArea><wicri:noRegion>Galway</wicri:noRegion></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation wicri:level="1"><nlm:aff id="I17">Surgery, Clinical Science Institute, Galway University Hospital and National University of Ireland, University Road, Galway, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Surgery, Clinical Science Institute, Galway University Hospital and National University of Ireland, University Road, Galway</wicri:regionArea><wicri:noRegion>Galway</wicri:noRegion></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation wicri:level="3"><nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I19">Unit Molecular Epidemiology C080, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Unit Molecular Epidemiology C080, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation wicri:level="3"><nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation wicri:level="3"><nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><affiliation wicri:level="3"><nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I20">National Center for Tumor Diseases, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation wicri:level="1"><nlm:aff id="I21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea><wicri:noRegion>75654 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I22">University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea><wicri:noRegion>75654 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Therese" last="Truong">Therese Truong</name><affiliation wicri:level="1"><nlm:aff id="I21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea><wicri:noRegion>75654 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I22">University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea><wicri:noRegion>75654 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Cordina, Emilie" sort="Cordina, Emilie" uniqKey="Cordina E" first="Emilie" last="Cordina">Emilie Cordina</name><affiliation wicri:level="1"><nlm:aff id="I21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea><wicri:noRegion>75654 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I22">University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea><wicri:noRegion>75654 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation wicri:level="1"><nlm:aff id="I21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea><wicri:noRegion>75654 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I22">University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea><wicri:noRegion>75654 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name><affiliation wicri:level="3"><nlm:aff id="I23">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I24">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation wicri:level="3"><nlm:aff id="I23">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I24">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation wicri:level="1"><nlm:aff id="I25">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, Herlev, 2730 Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, Herlev, 2730 Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Milne, Roger" sort="Milne, Roger" uniqKey="Milne R" first="Roger" last="Milne">Roger Milne</name><affiliation wicri:level="1"><nlm:aff id="I26">Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M Pilar" last="Zamora">M Pilar Zamora</name><affiliation wicri:level="1"><nlm:aff id="I27">Servicio de Oncología Médica, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Oncología Médica, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Perez">Jose Ignacio Arias Perez</name><affiliation wicri:level="1"><nlm:aff id="I28">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Avda. Dres. Fernández Vega, 107 Oviedo, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Avda. Dres. Fernández Vega, 107 Oviedo</wicri:regionArea><wicri:noRegion>107 Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation wicri:level="1"><nlm:aff id="I29">Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I30">Centro de Investigación en Red de Enfermedades Raras (CIBERER), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación en Red de Enfermedades Raras (CIBERER), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name><affiliation wicri:level="2"><nlm:aff id="I31">Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation wicri:level="1"><nlm:aff id="I32">Department of Epidemiology, School of Medicine, 224 Irvine Hall, University of California Irvine, Irvine, California 92697-7550, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Medicine, 224 Irvine Hall, University of California Irvine, Irvine, California 92697-7550</wicri:regionArea><wicri:noRegion>California 92697-7550</wicri:noRegion></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation wicri:level="1"><nlm:aff id="I32">Department of Epidemiology, School of Medicine, 224 Irvine Hall, University of California Irvine, Irvine, California 92697-7550, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Medicine, 224 Irvine Hall, University of California Irvine, Irvine, California 92697-7550</wicri:regionArea><wicri:noRegion>California 92697-7550</wicri:noRegion></affiliation></author><author><name sortKey="Clarke Dur, Christina" sort="Clarke Dur, Christina" uniqKey="Clarke Dur C" first="Christina" last="Clarke Dur">Christina Clarke Dur</name><affiliation wicri:level="1"><nlm:aff id="I33">Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, California 95438, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, California 95438</wicri:regionArea><wicri:noRegion>California 95438</wicri:noRegion></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:aff id="I34">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I35">German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name><affiliation wicri:level="3"><nlm:aff id="I34">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation wicri:level="3"><nlm:aff id="I34">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation wicri:level="3"><nlm:aff id="I34">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I35">German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="3"><nlm:aff id="I36">Clinic of Gynecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Ismaninger Strasse 22, D-81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic of Gynecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Ismaninger Strasse 22, D-81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Heil, Joerg" sort="Heil, Joerg" uniqKey="Heil J" first="Joerg" last="Heil">Joerg Heil</name><affiliation wicri:level="3"><nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Bartram, Claus R" sort="Bartram, Claus R" uniqKey="Bartram C" first="Claus R" last="Bartram">Claus R. Bartram</name><affiliation wicri:level="3"><nlm:aff id="I37">Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69121 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69121 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation wicri:level="3"><nlm:aff id="I38">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, Center of Molecular Medicine Cologne (CMMC), University Hospital of Cologne, ZMMK-Forschungsgebäude, Robert-Koch-Strasse 21, 50931 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, Center of Molecular Medicine Cologne (CMMC), University Hospital of Cologne, ZMMK-Forschungsgebäude, Robert-Koch-Strasse 21, 50931 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation wicri:level="3"><nlm:aff id="I39">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Robert Bosch Stiftung GmbH, Heidehofstrasse 31, 70184 Stuttgart, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Robert Bosch Stiftung GmbH, Heidehofstrasse 31, 70184 Stuttgart</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I40">University of Tübingen, Geschwister-Scholl-Platz, 72074 Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen, Geschwister-Scholl-Platz, 72074 Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name><affiliation wicri:level="3"><nlm:aff id="I39">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Robert Bosch Stiftung GmbH, Heidehofstrasse 31, 70184 Stuttgart, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Robert Bosch Stiftung GmbH, Heidehofstrasse 31, 70184 Stuttgart</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I40">University of Tübingen, Geschwister-Scholl-Platz, 72074 Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen, Geschwister-Scholl-Platz, 72074 Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation wicri:level="3"><nlm:aff id="I41">Department of Internal Medicine, Evangelische Kliniken Bonn GGmbH, Johanniter Krankenhaus, 53113 Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine, Evangelische Kliniken Bonn GGmbH, Johanniter Krankenhaus, 53113 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24887515</idno><idno type="pmc">4522594</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522594</idno><idno type="RBID">PMC:4522594</idno><idno type="doi">10.1186/bcr3662</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001627</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001627</idno><idno type="wicri:Area/Pmc/Curation">001487</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001487</idno><idno type="wicri:Area/Pmc/Checkpoint">001571</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001571</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">003792</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003792</idno><idno type="wicri:Area/PubMed/Curation">003678</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003678</idno><idno type="wicri:Area/PubMed/Checkpoint">003678</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003678</idno><idno type="wicri:Area/Ncbi/Merge">001A85</idno><idno type="wicri:Area/Ncbi/Curation">001A85</idno><idno type="wicri:Area/Ncbi/Checkpoint">001A85</idno><idno type="wicri:doubleKey">1465-5411:2014:Johnson N:genetic:variation:at</idno><idno type="wicri:Area/Main/Merge">003954</idno><idno type="wicri:Area/Main/Curation">003918</idno><idno type="wicri:Area/Main/Exploration">003918</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic variation at <italic>CYP3A</italic> is associated with age at menarche and breast cancer risk: a case-control study</title><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation wicri:level="1"><nlm:aff id="I1">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB</wicri:regionArea><wicri:noRegion>London SW3 6JB</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB</wicri:regionArea><wicri:noRegion>London SW3 6JB</wicri:noRegion></affiliation></author><author><name sortKey="Dudbridge, Frank" sort="Dudbridge, Frank" uniqKey="Dudbridge F" first="Frank" last="Dudbridge">Frank Dudbridge</name><affiliation wicri:level="1"><nlm:aff id="I3">Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT</wicri:regionArea><wicri:noRegion>London WC1E 7HT</wicri:noRegion></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation wicri:level="1"><nlm:aff id="I1">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB</wicri:regionArea><wicri:noRegion>London SW3 6JB</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB</wicri:regionArea><wicri:noRegion>London SW3 6JB</wicri:noRegion></affiliation></author><author><name sortKey="Gibson, Lorna" sort="Gibson, Lorna" uniqKey="Gibson L" first="Lorna" last="Gibson">Lorna Gibson</name><affiliation wicri:level="1"><nlm:aff id="I3">Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT</wicri:regionArea><wicri:noRegion>London WC1E 7HT</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Michael E" sort="Jones, Michael E" uniqKey="Jones M" first="Michael E" last="Jones">Michael E. Jones</name><affiliation wicri:level="1"><nlm:aff id="I4">Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J" last="Schoemaker">Minouk J. Schoemaker</name><affiliation wicri:level="1"><nlm:aff id="I4">Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Folkerd, Elizabeth J" sort="Folkerd, Elizabeth J" uniqKey="Folkerd E" first="Elizabeth J" last="Folkerd">Elizabeth J. Folkerd</name><affiliation wicri:level="1"><nlm:aff id="I5">The Academic Department of Biochemistry, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Academic Department of Biochemistry, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ</wicri:regionArea><wicri:noRegion>London SW3 6JJ</wicri:noRegion></affiliation></author><author><name sortKey="Haynes, Ben P" sort="Haynes, Ben P" uniqKey="Haynes B" first="Ben P" last="Haynes">Ben P. Haynes</name><affiliation wicri:level="1"><nlm:aff id="I5">The Academic Department of Biochemistry, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Academic Department of Biochemistry, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ</wicri:regionArea><wicri:noRegion>London SW3 6JJ</wicri:noRegion></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="I6">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation wicri:level="4"><nlm:aff id="I7">Genetic Epidemiology Department, Department of Pathology, The University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Department, Department of Pathology, The University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Dite, Gillian S" sort="Dite, Gillian S" uniqKey="Dite G" first="Gillian S" last="Dite">Gillian S. Dite</name><affiliation wicri:level="4"><nlm:aff id="I6">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation wicri:level="4"><nlm:aff id="I6">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name><affiliation wicri:level="1"><nlm:aff id="I8">Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation wicri:level="1"><nlm:aff id="I8">Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Van Veer, Laura J" sort="Van Veer, Laura J" uniqKey="Van Veer L" first="Laura J" last="Van Veer">Laura J. Van Veer</name><affiliation wicri:level="1"><nlm:aff id="I8">Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Atsma, Femke" sort="Atsma, Femke" uniqKey="Atsma F" first="Femke" last="Atsma">Femke Atsma</name><affiliation wicri:level="3"><nlm:aff id="I9">Sanquin, Radboud Universiteit Nijmegen, 6525 GA, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Sanquin, Radboud Universiteit Nijmegen, 6525 GA, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation wicri:level="1"><nlm:aff id="I10">Warwick Medical School, University of Warwick, Coventry CV4 7AJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Warwick Medical School, University of Warwick, Coventry CV4 7AJ</wicri:regionArea><wicri:noRegion>Coventry CV4 7AJ</wicri:noRegion></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation wicri:level="1"><nlm:aff id="I10">Warwick Medical School, University of Warwick, Coventry CV4 7AJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Warwick Medical School, University of Warwick, Coventry CV4 7AJ</wicri:regionArea><wicri:noRegion>Coventry CV4 7AJ</wicri:noRegion></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name><affiliation wicri:level="1"><nlm:aff id="I11">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Postfach 2306, D-91012 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Postfach 2306, D-91012 Erlangen</wicri:regionArea><wicri:noRegion>91012 Erlangen</wicri:noRegion><wicri:noRegion>91012 Erlangen</wicri:noRegion><wicri:noRegion>D-91012 Erlangen</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="I12">David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name><affiliation wicri:level="1"><nlm:aff id="I11">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Postfach 2306, D-91012 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Postfach 2306, D-91012 Erlangen</wicri:regionArea><wicri:noRegion>91012 Erlangen</wicri:noRegion><wicri:noRegion>91012 Erlangen</wicri:noRegion><wicri:noRegion>D-91012 Erlangen</wicri:noRegion></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B" last="Ekici">Arif B. Ekici</name><affiliation wicri:level="1"><nlm:aff id="I13">Institute of Human Genetics, Friedrich Alexander University Erlangen- Nuremberg, Schlossplatz 4, 91054 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Friedrich Alexander University Erlangen- Nuremberg, Schlossplatz 4, 91054 Erlangen</wicri:regionArea><wicri:noRegion>91054 Erlangen</wicri:noRegion><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Renner, Stefan P" sort="Renner, Stefan P" uniqKey="Renner S" first="Stefan P" last="Renner">Stefan P. Renner</name><affiliation wicri:level="1"><nlm:aff id="I11">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Postfach 2306, D-91012 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Postfach 2306, D-91012 Erlangen</wicri:regionArea><wicri:noRegion>91012 Erlangen</wicri:noRegion><wicri:noRegion>91012 Erlangen</wicri:noRegion><wicri:noRegion>D-91012 Erlangen</wicri:noRegion></affiliation></author><author><name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name><affiliation wicri:level="1"><nlm:aff id="I14">Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, Guy’s Hospital, Great Maze Pond, London SE1 9RT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, Guy’s Hospital, Great Maze Pond, London SE1 9RT</wicri:regionArea><wicri:noRegion>London SE1 9RT</wicri:noRegion></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation wicri:level="4"><nlm:aff id="I15">Welcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Welcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="I16">Oxford Biomedical Research Centre, University of Oxford, The Churchill Hospital, Old Road, Headington OX3 7LE Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Biomedical Research Centre, University of Oxford, The Churchill Hospital, Old Road, Headington OX3 7LE Oxford</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name><affiliation wicri:level="1"><nlm:aff id="I17">Surgery, Clinical Science Institute, Galway University Hospital and National University of Ireland, University Road, Galway, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Surgery, Clinical Science Institute, Galway University Hospital and National University of Ireland, University Road, Galway</wicri:regionArea><wicri:noRegion>Galway</wicri:noRegion></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation wicri:level="1"><nlm:aff id="I17">Surgery, Clinical Science Institute, Galway University Hospital and National University of Ireland, University Road, Galway, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Surgery, Clinical Science Institute, Galway University Hospital and National University of Ireland, University Road, Galway</wicri:regionArea><wicri:noRegion>Galway</wicri:noRegion></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation wicri:level="3"><nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I19">Unit Molecular Epidemiology C080, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Unit Molecular Epidemiology C080, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation wicri:level="3"><nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation wicri:level="3"><nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><affiliation wicri:level="3"><nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I20">National Center for Tumor Diseases, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation wicri:level="1"><nlm:aff id="I21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea><wicri:noRegion>75654 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I22">University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea><wicri:noRegion>75654 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Therese" last="Truong">Therese Truong</name><affiliation wicri:level="1"><nlm:aff id="I21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea><wicri:noRegion>75654 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I22">University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea><wicri:noRegion>75654 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Cordina, Emilie" sort="Cordina, Emilie" uniqKey="Cordina E" first="Emilie" last="Cordina">Emilie Cordina</name><affiliation wicri:level="1"><nlm:aff id="I21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea><wicri:noRegion>75654 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I22">University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea><wicri:noRegion>75654 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation wicri:level="1"><nlm:aff id="I21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea><wicri:noRegion>75654 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I22">University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654 Paris</wicri:regionArea><wicri:noRegion>75654 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name><affiliation wicri:level="3"><nlm:aff id="I23">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I24">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation wicri:level="3"><nlm:aff id="I23">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I24">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730 Herlev, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation wicri:level="1"><nlm:aff id="I25">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, Herlev, 2730 Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, Herlev, 2730 Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Milne, Roger" sort="Milne, Roger" uniqKey="Milne R" first="Roger" last="Milne">Roger Milne</name><affiliation wicri:level="1"><nlm:aff id="I26">Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M Pilar" last="Zamora">M Pilar Zamora</name><affiliation wicri:level="1"><nlm:aff id="I27">Servicio de Oncología Médica, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Oncología Médica, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Perez">Jose Ignacio Arias Perez</name><affiliation wicri:level="1"><nlm:aff id="I28">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Avda. Dres. Fernández Vega, 107 Oviedo, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Avda. Dres. Fernández Vega, 107 Oviedo</wicri:regionArea><wicri:noRegion>107 Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation wicri:level="1"><nlm:aff id="I29">Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I30">Centro de Investigación en Red de Enfermedades Raras (CIBERER), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación en Red de Enfermedades Raras (CIBERER), Calle de Melchor Fernandez Almagro, 3, 28029 Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name><affiliation wicri:level="2"><nlm:aff id="I31">Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation wicri:level="1"><nlm:aff id="I32">Department of Epidemiology, School of Medicine, 224 Irvine Hall, University of California Irvine, Irvine, California 92697-7550, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Medicine, 224 Irvine Hall, University of California Irvine, Irvine, California 92697-7550</wicri:regionArea><wicri:noRegion>California 92697-7550</wicri:noRegion></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation wicri:level="1"><nlm:aff id="I32">Department of Epidemiology, School of Medicine, 224 Irvine Hall, University of California Irvine, Irvine, California 92697-7550, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Medicine, 224 Irvine Hall, University of California Irvine, Irvine, California 92697-7550</wicri:regionArea><wicri:noRegion>California 92697-7550</wicri:noRegion></affiliation></author><author><name sortKey="Clarke Dur, Christina" sort="Clarke Dur, Christina" uniqKey="Clarke Dur C" first="Christina" last="Clarke Dur">Christina Clarke Dur</name><affiliation wicri:level="1"><nlm:aff id="I33">Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, California 95438, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, California 95438</wicri:regionArea><wicri:noRegion>California 95438</wicri:noRegion></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:aff id="I34">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I35">German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name><affiliation wicri:level="3"><nlm:aff id="I34">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation wicri:level="3"><nlm:aff id="I34">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation wicri:level="3"><nlm:aff id="I34">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I35">German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="3"><nlm:aff id="I36">Clinic of Gynecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Ismaninger Strasse 22, D-81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic of Gynecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Ismaninger Strasse 22, D-81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Heil, Joerg" sort="Heil, Joerg" uniqKey="Heil J" first="Joerg" last="Heil">Joerg Heil</name><affiliation wicri:level="3"><nlm:aff id="I18">Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Bartram, Claus R" sort="Bartram, Claus R" uniqKey="Bartram C" first="Claus R" last="Bartram">Claus R. Bartram</name><affiliation wicri:level="3"><nlm:aff id="I37">Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69121 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69121 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation wicri:level="3"><nlm:aff id="I38">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, Center of Molecular Medicine Cologne (CMMC), University Hospital of Cologne, ZMMK-Forschungsgebäude, Robert-Koch-Strasse 21, 50931 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, Center of Molecular Medicine Cologne (CMMC), University Hospital of Cologne, ZMMK-Forschungsgebäude, Robert-Koch-Strasse 21, 50931 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation wicri:level="3"><nlm:aff id="I39">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Robert Bosch Stiftung GmbH, Heidehofstrasse 31, 70184 Stuttgart, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Robert Bosch Stiftung GmbH, Heidehofstrasse 31, 70184 Stuttgart</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I40">University of Tübingen, Geschwister-Scholl-Platz, 72074 Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen, Geschwister-Scholl-Platz, 72074 Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name><affiliation wicri:level="3"><nlm:aff id="I39">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Robert Bosch Stiftung GmbH, Heidehofstrasse 31, 70184 Stuttgart, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Robert Bosch Stiftung GmbH, Heidehofstrasse 31, 70184 Stuttgart</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I40">University of Tübingen, Geschwister-Scholl-Platz, 72074 Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen, Geschwister-Scholl-Platz, 72074 Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation wicri:level="3"><nlm:aff id="I41">Department of Internal Medicine, Evangelische Kliniken Bonn GGmbH, Johanniter Krankenhaus, 53113 Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine, Evangelische Kliniken Bonn GGmbH, Johanniter Krankenhaus, 53113 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author></analytic><series><title level="j">Breast Cancer Research : BCR</title><idno type="ISSN">1465-5411</idno><idno type="eISSN">1465-542X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Age of Onset</term><term>Aged</term><term>Breast Neoplasms (genetics)</term><term>Breast Neoplasms (pathology)</term><term>Cytochrome P-450 CYP3A (genetics)</term><term>European Continental Ancestry Group</term><term>Female</term><term>Genetic Association Studies</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Menarche (genetics)</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Premenopause (genetics)</term><term>Reproductive History</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antécédents gynécologiques et obstétricaux</term><term>Cytochrome P-450 CYP3A (génétique)</term><term>Facteurs de l'âge</term><term>Facteurs de risque</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Ménarche (génétique)</term><term>Polymorphisme de nucléotide simple</term><term>Population d'origine européenne</term><term>Prédisposition génétique à une maladie</term><term>Préménopause (génétique)</term><term>Sujet âgé</term><term>Tumeurs du sein (anatomopathologie)</term><term>Tumeurs du sein (génétique)</term><term>Âge de début</term><term>Études d'associations génétiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytochrome P-450 CYP3A</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term><term>Menarche</term><term>Premenopause</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cytochrome P-450 CYP3A</term><term>Ménarche</term><term>Préménopause</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Age of Onset</term><term>Aged</term><term>European Continental Ancestry Group</term><term>Female</term><term>Genetic Association Studies</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Reproductive History</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antécédents gynécologiques et obstétricaux</term><term>Facteurs de l'âge</term><term>Facteurs de risque</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Polymorphisme de nucléotide simple</term><term>Population d'origine européenne</term><term>Prédisposition génétique à une maladie</term><term>Sujet âgé</term><term>Âge de début</term><term>Études d'associations génétiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the <italic>CYP3A</italic> locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years.</p></sec><sec><title>Methods</title><p>We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.</p></sec><sec><title>Results</title><p>We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; <italic>P</italic> = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; <italic>P</italic> = 0.004), respectively (<italic>P</italic><sub>trend</sub> = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (<italic>P</italic><sub>trend</sub> = 0.005) but not cases (<italic>P</italic><sub>trend</sub> = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (<italic>P</italic><sub>het</sub> = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (OR<sub>het</sub> = 0.84, 95% CI 0.75, 0.94; OR<sub>hom</sub> = 0.81, 95% CI 0.51, 1.30; <italic>P</italic><sub>trend</sub> = 0.002) but not for those who had their menarche age ≤11 years (OR<sub>het</sub> = 1.06, 95% CI 0.95, 1.19, OR<sub>hom</sub> = 1.07, 95% CI 0.67, 1.72; <italic>P</italic><sub>trend</sub> = 0.29).</p></sec><sec><title>Conclusions</title><p>To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lichtenstein, P" uniqKey="Lichtenstein P">P Lichtenstein</name></author><author><name sortKey="Holm, Nv" uniqKey="Holm N">NV Holm</name></author><author><name sortKey="Verkasalo, Pk" uniqKey="Verkasalo P">PK Verkasalo</name></author><author><name sortKey="Iliadou, A" uniqKey="Iliadou A">A Iliadou</name></author><author><name sortKey="Kaprio, J" uniqKey="Kaprio J">J Kaprio</name></author><author><name sortKey="Koskenvuo, M" uniqKey="Koskenvuo M">M Koskenvuo</name></author><author><name sortKey="Pukkala, E" uniqKey="Pukkala E">E Pukkala</name></author><author><name sortKey="Skytthe, A" uniqKey="Skytthe A">A Skytthe</name></author><author><name sortKey="Hemminki, K" uniqKey="Hemminki K">K Hemminki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peto, J" uniqKey="Peto J">J Peto</name></author><author><name sortKey="Mack, Tm" uniqKey="Mack T">TM Mack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pharoah, Pd" uniqKey="Pharoah P">PD Pharoah</name></author><author><name sortKey="Antoniou, A" uniqKey="Antoniou A">A Antoniou</name></author><author><name sortKey="Bobrow, M" uniqKey="Bobrow M">M Bobrow</name></author><author><name sortKey="Zimmern, Rl" uniqKey="Zimmern R">RL Zimmern</name></author><author><name sortKey="Easton, Df" uniqKey="Easton D">DF Easton</name></author><author><name sortKey="Ponder, Ba" uniqKey="Ponder B">BA Ponder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Michailidou, K" uniqKey="Michailidou K">K Michailidou</name></author><author><name sortKey="Hall, P" uniqKey="Hall P">P Hall</name></author><author><name sortKey="Gonzalez Neira, A" uniqKey="Gonzalez Neira A">A Gonzalez-Neira</name></author><author><name sortKey="Ghoussaini, M" uniqKey="Ghoussaini M">M Ghoussaini</name></author><author><name sortKey="Dennis, J" uniqKey="Dennis J">J Dennis</name></author><author><name sortKey="Milne, Rl" uniqKey="Milne R">RL Milne</name></author><author><name sortKey="Schmidt, Mk" uniqKey="Schmidt M">MK Schmidt</name></author><author><name sortKey="Chang Claude, J" uniqKey="Chang Claude J">J Chang-Claude</name></author><author><name sortKey="Bojesen, Se" uniqKey="Bojesen S">SE Bojesen</name></author><author><name sortKey="Bolla, Mk" uniqKey="Bolla M">MK Bolla</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Dicks, E" uniqKey="Dicks E">E Dicks</name></author><author><name sortKey="Lee, A" uniqKey="Lee A">A Lee</name></author><author><name sortKey="Turnbull, C" uniqKey="Turnbull C">C Turnbull</name></author><author><name sortKey="Rahman, N" uniqKey="Rahman N">N Rahman</name></author><author><name sortKey="Fletcher, O" uniqKey="Fletcher O">O Fletcher</name></author><author><name sortKey="Peto, J" uniqKey="Peto J">J Peto</name></author><author><name sortKey="Gibson, L" uniqKey="Gibson L">L Gibson</name></author><author><name sortKey="Dos Santos Silva, I" uniqKey="Dos Santos Silva I">I Dos Santos Silva</name></author><author><name sortKey="Nevanlinna, H" uniqKey="Nevanlinna H">H Nevanlinna</name></author><author><name sortKey="Muranen, Ta" uniqKey="Muranen T">TA Muranen</name></author><author><name sortKey="Aittomaki, K" uniqKey="Aittomaki K">K Aittomaki</name></author><author><name sortKey="Blomqvist, C" uniqKey="Blomqvist C">C Blomqvist</name></author><author><name sortKey="Czene, K" uniqKey="Czene K">K Czene</name></author><author><name sortKey="Irwanto, A" uniqKey="Irwanto A">A Irwanto</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Waisfisz, Q" uniqKey="Waisfisz Q">Q Waisfisz</name></author><author><name sortKey="Meijers Heijboer, H" uniqKey="Meijers Heijboer H">H Meijers-Heijboer</name></author><author><name sortKey="Adank, M" uniqKey="Adank M">M Adank</name></author><author><name sortKey="Van Der Luijt, Rb" uniqKey="Van Der Luijt R">RB van der Luijt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia Closas, M" uniqKey="Garcia Closas M">M Garcia-Closas</name></author><author><name sortKey="Couch, Fj" uniqKey="Couch F">FJ Couch</name></author><author><name sortKey="Lindstrom, S" uniqKey="Lindstrom S">S Lindstrom</name></author><author><name sortKey="Michailidou, K" uniqKey="Michailidou K">K Michailidou</name></author><author><name sortKey="Schmidt, Mk" uniqKey="Schmidt M">MK Schmidt</name></author><author><name sortKey="Brook, Mn" uniqKey="Brook M">MN Brook</name></author><author><name sortKey="Orr, N" uniqKey="Orr N">N Orr</name></author><author><name sortKey="Rhie, Sk" uniqKey="Rhie S">SK Rhie</name></author><author><name sortKey="Riboli, E" uniqKey="Riboli E">E Riboli</name></author><author><name sortKey="Feigelson, Hs" uniqKey="Feigelson H">HS Feigelson</name></author><author><name sortKey="Le Marchand, L" uniqKey="Le Marchand L">L Le Marchand</name></author><author><name sortKey="Buring, Je" uniqKey="Buring J">JE Buring</name></author><author><name sortKey="Eccles, D" uniqKey="Eccles D">D Eccles</name></author><author><name sortKey="Miron, P" uniqKey="Miron P">P Miron</name></author><author><name sortKey="Fasching, Pa" uniqKey="Fasching P">PA Fasching</name></author><author><name sortKey="Brauch, H" uniqKey="Brauch H">H Brauch</name></author><author><name sortKey="Chang Claude, J" uniqKey="Chang Claude J">J Chang-Claude</name></author><author><name sortKey="Carpenter, J" uniqKey="Carpenter J">J Carpenter</name></author><author><name sortKey="Godwin, Ak" uniqKey="Godwin A">AK Godwin</name></author><author><name sortKey="Nevanlinna, H" uniqKey="Nevanlinna H">H Nevanlinna</name></author><author><name sortKey="Giles, Gg" uniqKey="Giles G">GG Giles</name></author><author><name sortKey="Cox, A" uniqKey="Cox A">A Cox</name></author><author><name sortKey="Hopper, Jl" uniqKey="Hopper J">JL Hopper</name></author><author><name sortKey="Bolla, Mk" uniqKey="Bolla M">MK Bolla</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Dennis, J" uniqKey="Dennis J">J Dennis</name></author><author><name sortKey="Dicks, E" uniqKey="Dicks E">E Dicks</name></author><author><name sortKey="Howat, Wj" uniqKey="Howat W">WJ Howat</name></author><author><name sortKey="Schoof, N" uniqKey="Schoof N">N Schoof</name></author><author><name sortKey="Bojesen, Se" uniqKey="Bojesen S">SE Bojesen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dunning, Am" uniqKey="Dunning A">AM Dunning</name></author><author><name sortKey="Dowsett, M" uniqKey="Dowsett M">M Dowsett</name></author><author><name sortKey="Healey, Cs" uniqKey="Healey C">CS Healey</name></author><author><name sortKey="Tee, L" uniqKey="Tee L">L Tee</name></author><author><name sortKey="Luben, Rn" uniqKey="Luben R">RN Luben</name></author><author><name sortKey="Folkerd, E" uniqKey="Folkerd E">E Folkerd</name></author><author><name sortKey="Novik, Kl" uniqKey="Novik K">KL Novik</name></author><author><name sortKey="Kelemen, L" uniqKey="Kelemen L">L Kelemen</name></author><author><name sortKey="Ogata, S" uniqKey="Ogata S">S Ogata</name></author><author><name sortKey="Pharoah, Pd" uniqKey="Pharoah P">PD Pharoah</name></author><author><name sortKey="Easton, Df" uniqKey="Easton D">DF Easton</name></author><author><name sortKey="Day, Ne" uniqKey="Day N">NE Day</name></author><author><name sortKey="Ponder, Ba" uniqKey="Ponder B">BA Ponder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Key, T" uniqKey="Key T">T Key</name></author><author><name sortKey="Appleby, P" uniqKey="Appleby P">P Appleby</name></author><author><name sortKey="Barnes, I" uniqKey="Barnes I">I Barnes</name></author><author><name sortKey="Reeves, G" uniqKey="Reeves G">G Reeves</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walker, K" uniqKey="Walker K">K Walker</name></author><author><name sortKey="Bratton, Dj" uniqKey="Bratton D">DJ Bratton</name></author><author><name sortKey="Frost, C" uniqKey="Frost C">C Frost</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fortner, Rt" uniqKey="Fortner R">RT Fortner</name></author><author><name sortKey="Eliassen, Ah" uniqKey="Eliassen A">AH Eliassen</name></author><author><name sortKey="Spiegelman, D" uniqKey="Spiegelman D">D Spiegelman</name></author><author><name sortKey="Willett, Wc" uniqKey="Willett W">WC Willett</name></author><author><name sortKey="Barbieri, Rl" uniqKey="Barbieri R">RL Barbieri</name></author><author><name sortKey="Hankinson, Se" uniqKey="Hankinson S">SE Hankinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Helzlsouer, Kj" uniqKey="Helzlsouer K">KJ Helzlsouer</name></author><author><name sortKey="Alberg, Aj" uniqKey="Alberg A">AJ Alberg</name></author><author><name sortKey="Bush, Tl" uniqKey="Bush T">TL Bush</name></author><author><name sortKey="Longcope, C" uniqKey="Longcope C">C Longcope</name></author><author><name sortKey="Gordon, Gb" uniqKey="Gordon G">GB Gordon</name></author><author><name sortKey="Comstock, Gw" uniqKey="Comstock G">GW Comstock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wysowski, Dk" uniqKey="Wysowski D">DK Wysowski</name></author><author><name sortKey="Comstock, Gw" uniqKey="Comstock G">GW Comstock</name></author><author><name sortKey="Helsing, Kj" uniqKey="Helsing K">KJ Helsing</name></author><author><name sortKey="Lau, Hl" uniqKey="Lau H">HL Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosenberg, Cr" uniqKey="Rosenberg C">CR Rosenberg</name></author><author><name sortKey="Pasternack, Bs" uniqKey="Pasternack B">BS Pasternack</name></author><author><name sortKey="Shore, Re" uniqKey="Shore R">RE Shore</name></author><author><name sortKey="Koenig, Kl" uniqKey="Koenig K">KL Koenig</name></author><author><name sortKey="Toniolo, Pg" uniqKey="Toniolo P">PG Toniolo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, Hv" uniqKey="Thomas H">HV Thomas</name></author><author><name sortKey="Key, Tj" uniqKey="Key T">TJ Key</name></author><author><name sortKey="Allen, Ds" uniqKey="Allen D">DS Allen</name></author><author><name sortKey="Moore, Jw" uniqKey="Moore J">JW Moore</name></author><author><name sortKey="Dowsett, M" uniqKey="Dowsett M">M Dowsett</name></author><author><name sortKey="Fentiman, Is" uniqKey="Fentiman I">IS Fentiman</name></author><author><name sortKey="Wang, Dy" uniqKey="Wang D">DY Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kabuto, M" uniqKey="Kabuto M">M Kabuto</name></author><author><name sortKey="Akiba, S" uniqKey="Akiba S">S Akiba</name></author><author><name sortKey="Stevens, Rg" uniqKey="Stevens R">RG Stevens</name></author><author><name sortKey="Neriishi, K" uniqKey="Neriishi K">K Neriishi</name></author><author><name sortKey="Land, Ce" uniqKey="Land C">CE Land</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaaks, R" uniqKey="Kaaks R">R Kaaks</name></author><author><name sortKey="Berrino, F" uniqKey="Berrino F">F Berrino</name></author><author><name sortKey="Key, T" uniqKey="Key T">T Key</name></author><author><name sortKey="Rinaldi, S" uniqKey="Rinaldi S">S Rinaldi</name></author><author><name sortKey="Dossus, L" uniqKey="Dossus L">L Dossus</name></author><author><name sortKey="Biessy, C" uniqKey="Biessy C">C Biessy</name></author><author><name sortKey="Secreto, G" uniqKey="Secreto G">G Secreto</name></author><author><name sortKey="Amiano, P" uniqKey="Amiano P">P Amiano</name></author><author><name sortKey="Bingham, S" uniqKey="Bingham S">S Bingham</name></author><author><name sortKey="Boeing, H" uniqKey="Boeing H">H Boeing</name></author><author><name sortKey="De Mesquita Hb, B" uniqKey="De Mesquita Hb B">B de Mesquita HB</name></author><author><name sortKey="Chang Claude, J" uniqKey="Chang Claude J">J Chang-Claude</name></author><author><name sortKey="Clavel Chapelon, F" uniqKey="Clavel Chapelon F">F Clavel-Chapelon</name></author><author><name sortKey="Fournier, A" uniqKey="Fournier A">A Fournier</name></author><author><name sortKey="Van Gils, Ch" uniqKey="Van Gils C">CH van Gils</name></author><author><name sortKey="Gonzalez, Ca" uniqKey="Gonzalez C">CA Gonzalez</name></author><author><name sortKey="Gurrea, Ab" uniqKey="Gurrea A">AB Gurrea</name></author><author><name sortKey="Critselis, E" uniqKey="Critselis E">E Critselis</name></author><author><name sortKey="Khaw, Kt" uniqKey="Khaw K">KT Khaw</name></author><author><name sortKey="Krogh, V" uniqKey="Krogh V">V Krogh</name></author><author><name sortKey="Lahmann, Ph" uniqKey="Lahmann P">PH Lahmann</name></author><author><name sortKey="Nagel, G" uniqKey="Nagel G">G Nagel</name></author><author><name sortKey="Olsen, A" uniqKey="Olsen A">A Olsen</name></author><author><name sortKey="Onland Moret, Nc" uniqKey="Onland Moret N">NC Onland-Moret</name></author><author><name sortKey="Overvad, K" uniqKey="Overvad K">K Overvad</name></author><author><name sortKey="Palli, D" uniqKey="Palli D">D Palli</name></author><author><name sortKey="Panico, S" uniqKey="Panico S">S Panico</name></author><author><name sortKey="Peeters, P" uniqKey="Peeters P">P Peeters</name></author><author><name sortKey="Quiros, Jr" uniqKey="Quiros J">JR Quiros</name></author><author><name sortKey="Roddam, A" uniqKey="Roddam A">A Roddam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eliassen, Ah" uniqKey="Eliassen A">AH Eliassen</name></author><author><name sortKey="Missmer, Sa" uniqKey="Missmer S">SA Missmer</name></author><author><name sortKey="Tworoger, Ss" uniqKey="Tworoger S">SS Tworoger</name></author><author><name sortKey="Spiegelman, D" uniqKey="Spiegelman D">D Spiegelman</name></author><author><name sortKey="Barbieri, Rl" uniqKey="Barbieri R">RL Barbieri</name></author><author><name sortKey="Dowsett, M" uniqKey="Dowsett M">M Dowsett</name></author><author><name sortKey="Hankinson, Se" uniqKey="Hankinson S">SE Hankinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stone, J" uniqKey="Stone J">J Stone</name></author><author><name sortKey="Folkerd, E" uniqKey="Folkerd E">E Folkerd</name></author><author><name sortKey="Doody, D" uniqKey="Doody D">D Doody</name></author><author><name sortKey="Schroen, C" uniqKey="Schroen C">C Schroen</name></author><author><name sortKey="Treloar, Sa" uniqKey="Treloar S">SA Treloar</name></author><author><name sortKey="Giles, Gg" uniqKey="Giles G">GG Giles</name></author><author><name sortKey="Pike, Mc" uniqKey="Pike M">MC Pike</name></author><author><name sortKey="English, Dr" uniqKey="English D">DR English</name></author><author><name sortKey="Southey, Mc" uniqKey="Southey M">MC Southey</name></author><author><name sortKey="Hopper, Jl" uniqKey="Hopper J">JL Hopper</name></author><author><name sortKey="Dowsett, M" uniqKey="Dowsett M">M Dowsett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, N" uniqKey="Johnson N">N Johnson</name></author><author><name sortKey="Walker, K" uniqKey="Walker K">K Walker</name></author><author><name sortKey="Gibson, Lj" uniqKey="Gibson L">LJ Gibson</name></author><author><name sortKey="Orr, N" uniqKey="Orr N">N Orr</name></author><author><name sortKey="Folkerd, E" uniqKey="Folkerd E">E Folkerd</name></author><author><name sortKey="Haynes, B" uniqKey="Haynes B">B Haynes</name></author><author><name sortKey="Palles, C" uniqKey="Palles C">C Palles</name></author><author><name sortKey="Coupland, B" uniqKey="Coupland B">B Coupland</name></author><author><name sortKey="Schoemaker, M" uniqKey="Schoemaker M">M Schoemaker</name></author><author><name sortKey="Jones, M" uniqKey="Jones M">M Jones</name></author><author><name sortKey="Broderick, P" uniqKey="Broderick P">P Broderick</name></author><author><name sortKey="Sawyer, E" uniqKey="Sawyer E">E Sawyer</name></author><author><name sortKey="Kerin, M" uniqKey="Kerin M">M Kerin</name></author><author><name sortKey="Tomlinson, Ip" uniqKey="Tomlinson I">IP Tomlinson</name></author><author><name sortKey="Zvelebil, M" uniqKey="Zvelebil M">M Zvelebil</name></author><author><name sortKey="Chilcott Burns, S" uniqKey="Chilcott Burns S">S Chilcott-Burns</name></author><author><name sortKey="Tomczyk, K" uniqKey="Tomczyk K">K Tomczyk</name></author><author><name sortKey="Simpson, G" uniqKey="Simpson G">G Simpson</name></author><author><name sortKey="Williamson, J" uniqKey="Williamson J">J Williamson</name></author><author><name sortKey="Hillier, Sg" uniqKey="Hillier S">SG Hillier</name></author><author><name sortKey="Ross, G" uniqKey="Ross G">G Ross</name></author><author><name sortKey="Houlston, Rs" uniqKey="Houlston R">RS Houlston</name></author><author><name sortKey="Swerdlow, A" uniqKey="Swerdlow A">A Swerdlow</name></author><author><name sortKey="Ashworth, A" uniqKey="Ashworth A">A Ashworth</name></author><author><name sortKey="Dowsett, M" uniqKey="Dowsett M">M Dowsett</name></author><author><name sortKey="Peto, J" uniqKey="Peto J">J Peto</name></author><author><name sortKey="Dos Santos Silva, I" uniqKey="Dos Santos Silva I">I Dos Santos Silva</name></author><author><name sortKey="Fletcher, O" uniqKey="Fletcher O">O Fletcher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Higgins, Jp" uniqKey="Higgins J">JP Higgins</name></author><author><name sortKey="Thompson, Sg" uniqKey="Thompson S">SG Thompson</name></author><author><name sortKey="Deeks, Jj" uniqKey="Deeks J">JJ Deeks</name></author><author><name sortKey="Altman, Dg" uniqKey="Altman D">DG Altman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dvornyk, V" uniqKey="Dvornyk V">V Dvornyk</name></author><author><name sortKey="Waqar Ul, H" uniqKey="Waqar Ul H">H Waqar ul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, C" uniqKey="He C">C He</name></author><author><name sortKey="Murabito, Jm" uniqKey="Murabito J">JM Murabito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colditz, Ga" uniqKey="Colditz G">GA Colditz</name></author><author><name sortKey="Baer, Hj" uniqKey="Baer H">HJ Baer</name></author><author><name sortKey="Tamimi, Rm" uniqKey="Tamimi R">RM Tamimi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prescott, J" uniqKey="Prescott J">J Prescott</name></author><author><name sortKey="Thompson, Dj" uniqKey="Thompson D">DJ Thompson</name></author><author><name sortKey="Kraft, P" uniqKey="Kraft P">P Kraft</name></author><author><name sortKey="Chanock, Sj" uniqKey="Chanock S">SJ Chanock</name></author><author><name sortKey="Audley, T" uniqKey="Audley T">T Audley</name></author><author><name sortKey="Brown, J" uniqKey="Brown J">J Brown</name></author><author><name sortKey="Leyland, J" uniqKey="Leyland J">J Leyland</name></author><author><name sortKey="Folkerd, E" uniqKey="Folkerd E">E Folkerd</name></author><author><name sortKey="Doody, D" uniqKey="Doody D">D Doody</name></author><author><name sortKey="Hankinson, Se" uniqKey="Hankinson S">SE Hankinson</name></author><author><name sortKey="Hunter, Dj" uniqKey="Hunter D">DJ Hunter</name></author><author><name sortKey="Jacobs, Kb" uniqKey="Jacobs K">KB Jacobs</name></author><author><name sortKey="Dowsett, M" uniqKey="Dowsett M">M Dowsett</name></author><author><name sortKey="Cox, Dg" uniqKey="Cox D">DG Cox</name></author><author><name sortKey="Easton, Df" uniqKey="Easton D">DF Easton</name></author><author><name sortKey="De Vivo, I" uniqKey="De Vivo I">I De Vivo</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Irlande (pays)</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Bavière</li><li>Californie</li><li>Communauté de Madrid</li><li>District de Cologne</li><li>District de Haute-Bavière</li><li>District de Karlsruhe</li><li>District de Moyenne-Franconie</li><li>District de Stuttgart</li><li>District de Tübingen</li><li>Gueldre</li><li>Hollande-Septentrionale</li><li>Hovedstaden</li><li>Oxfordshire</li><li>Rhénanie-du-Nord-Westphalie</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Bonn</li><li>Cologne</li><li>Copenhague</li><li>Erlangen</li><li>Heidelberg</li><li>Madrid</li><li>Melbourne</li><li>Munich</li><li>Nimègue</li><li>Oxford</li><li>Paris</li><li>Stuttgart</li><li>Tübingen</li></settlement><orgName><li>Université d'Oxford</li><li>Université de Melbourne</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name></noRegion><name sortKey="Dudbridge, Frank" sort="Dudbridge, Frank" uniqKey="Dudbridge F" first="Frank" last="Dudbridge">Frank Dudbridge</name><name sortKey="Folkerd, Elizabeth J" sort="Folkerd, Elizabeth J" uniqKey="Folkerd E" first="Elizabeth J" last="Folkerd">Elizabeth J. Folkerd</name><name sortKey="Gibson, Lorna" sort="Gibson, Lorna" uniqKey="Gibson L" first="Lorna" last="Gibson">Lorna Gibson</name><name sortKey="Haynes, Ben P" sort="Haynes, Ben P" uniqKey="Haynes B" first="Ben P" last="Haynes">Ben P. Haynes</name><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><name sortKey="Jones, Michael E" sort="Jones, Michael E" uniqKey="Jones M" first="Michael E" last="Jones">Michael E. Jones</name><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J" last="Schoemaker">Minouk J. Schoemaker</name><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name></region><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><name sortKey="Dite, Gillian S" sort="Dite, Gillian S" uniqKey="Dite G" first="Gillian S" last="Dite">Gillian S. Dite</name><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name></region><name sortKey="Atsma, Femke" sort="Atsma, Femke" uniqKey="Atsma F" first="Femke" last="Atsma">Femke Atsma</name><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><name sortKey="Van Veer, Laura J" sort="Van Veer, Laura J" uniqKey="Van Veer L" first="Laura J" last="Van Veer">Laura J. Van Veer</name></country><country name="Allemagne"><noRegion><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name></noRegion><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><name sortKey="Bartram, Claus R" sort="Bartram, Claus R" uniqKey="Bartram C" first="Claus R" last="Bartram">Claus R. Bartram</name><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B" last="Ekici">Arif B. Ekici</name><name sortKey="Heil, Joerg" sort="Heil, Joerg" uniqKey="Heil J" first="Joerg" last="Heil">Joerg Heil</name><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name><name sortKey="Renner, Stefan P" sort="Renner, Stefan P" uniqKey="Renner S" first="Stefan P" last="Renner">Stefan P. Renner</name><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name></region><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name><name sortKey="Clarke Dur, Christina" sort="Clarke Dur, Christina" uniqKey="Clarke Dur C" first="Christina" last="Clarke Dur">Christina Clarke Dur</name><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name></noRegion><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name></country><country name="France"><region name="Île-de-France"><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name></region><name sortKey="Cordina, Emilie" sort="Cordina, Emilie" uniqKey="Cordina E" first="Emilie" last="Cordina">Emilie Cordina</name><name sortKey="Cordina, Emilie" sort="Cordina, Emilie" uniqKey="Cordina E" first="Emilie" last="Cordina">Emilie Cordina</name><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Therese" last="Truong">Therese Truong</name><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Therese" last="Truong">Therese Truong</name></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name></region><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Milne, Roger" sort="Milne, Roger" uniqKey="Milne R" first="Roger" last="Milne">Roger Milne</name></region><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Perez">Jose Ignacio Arias Perez</name><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M Pilar" last="Zamora">M Pilar Zamora</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003918 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003918 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4522594
|texte= Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24887515" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |